Jens Hillengass, MD
BUFFALO, N.Y. — A single infusion of the CAR T cell therapy ciltacabtagene autoleucel produced deep, durable responses in multiple myeloma patients whose disease had progressed less than a year after autologous stem cell transplant (ASCT) or who experienced relapse after receiving up to three lines of initial therapy, as seen in the latest follow-up data for two cohorts of participants in the phase 2 clinical trial CARTITUDE-2 (NCT04133636, ASH 2023 abstract 1021). Jens Hillengass, MD, PhD, Chief of Myeloma at Roswell Park Comprehensive Cancer Center, shared the updated results in an oral abstract session Monday, Dec. 11, during the American Society of Hematology (ASH) annual meeting in San Diego, California.
FDA-approved in 2022 for the treatment of relapsed or refractory multiple myeloma with at least four prior lines of therapy, ciltacabtagene autoleucel (cilta-cel; brand name Carvykti) is a type of chimeric antigen receptor (CAR) T-cell therapy that engineers the patient’s own T cells to target the B-cell maturation antigen (BCMA), which is expressed on multiple myeloma cancer cells but not on most other cells.
CARTITUDE-2 was designed to evaluate the safety and efficacy of cilta-cel. Sponsored by Janssen Research and Development LLC and launched in November 2019, it enrolled 169 multiple myeloma patients, who were divided into eight cohorts with various characteristics. The current ASH presentation focuses on follow-up results for patients in two of those groups: Cohort A, who had received between one and three prior lines of therapy (LOT) and whose disease was refractory to lenalidomide, a standard of care medication, and Cohort B, who had relapsed a year or less after either autologous stem cell transplant (ASCT) or the beginning of initial anti-myeloma treatment if they did not undergo ASCT.
Follow-up data on those two cohorts were reported previously at 17 and 18 months, respectively. The oral abstract at ASH brings those…
Read the full article here
