BUFFALO, N.Y. and SOMERVILLE, Mass. – Roswell Park Comprehensive Cancer Center and Generate:Biomedicines announce a strategic collaboration to discover and develop chimeric antigen receptor (CAR) T-cell therapies, and armoring technologies, for up to three oncology targets, including in ovarian cancer and other solid tumors. In ovarian cancer alone, an estimated 314,000 women worldwide are diagnosed and over 200,000 women die each year.
Under the collaboration agreement, Roswell Park and Generate:Biomedicines will contribute toward creating optimized cell therapies, where a patient’s T cells are engineered to recognize and kill tumors. In recent years, CAR T-cells have seen remarkable successes for the treatment of liquid tumors, such as leukemia and lymphoma, including FDA approvals; however, successful treatment of solid tumors remains a major challenge for the field.
The collaboration combines the programmability and scalability of The Generate Platform and Roswell Park’s expertise in cell therapy design, clinical development, and manufacturing to bring best-in-class cell therapies to patients. The collaboration continues the significant momentum associated with the recently announced expansion, supported in part by New York State funds, that will make Roswell Park’s Current Good Manufacturing Practice (cGMP) facilities the largest academic cell therapy center in the United States.
“This is a powerful combination that brings together Roswell Park’s world-leading expertise in cell therapy manufacturing and our technology and computational power,” says Generate:Biomedicines’ Executive Vice President, Research & Development, Alex Snyder, MD. “Dr. Brentjens – whose lab played a foundational role in development of the currently approved therapies – together with Dr. Davila and their team are among the world’s leading experts in cell therapy. Together we will deliver novel CAR T-cell therapeutics rapidly to change outcomes for…
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